Friday, December 29, 2023

 


 septic arthritis, and cellulitis, to potentially

life-threatening infections, including Kawasaki disease,

meningitis, bacteremia, and sepsis. Because the differential

diagnosis is so broad, and fever is so common, the

approach to the febrile child is based on several factors,

including age, clinical impression (well or ill-appearing),

physical examination (source or no source), and risk

stratification (high or low risk for SBI) (Figure 48- 1).

Febrile infants <30 days old, even if they are well

appearing, should have a full septic work-up, which includes

complete blood count with manual differential, blood culture, urinalysis, urine culture, and lumbar puncture. CSF

should be sent for cell count, protein and glucose levels,

Gram stain, and culture. Herpes simplex virus (HSV) polymerase chain reaction should be considered in neonates

and those who are high risk. Urine must be collected in a

sterile manner, using bladder catheterization or suprapubic

aspiration. Bagged specimens are not helpful and are fre ­

quently contaminated by skin flora. Based on symptoms,

additional studies may be considered; liver function testing

should be assessed if an infant presents with j aundice, and

stool studies can be sent if diarrhea is present.

Well appearing infants age 1-3 months are classified

as low or high risk for SBI. Their risk stratification is

dependent on history, physical exam, and basic initial lab

results. To qualify as low risk, an infant must be previously

healthy without any comorbidity, nontoxic appearing,

without a focus of infection (excluding otitis media), demonstrate normal lab values, and have reliable caregivers

who can ensure close follow-up. The Rochester Criteria,

the Philadelphia Protocol, and the Boston Criteria are the

IV antibiotics;

admit

PEDIATRIC FEVER

History and physical exam to identify source of fever �

LP; IV

antibiotics;

admit

+/- 1M

antibiotics;

discharge with

24-hr follow-up

(if antibiotics

g iven, perform

LP}

No antibiotics

Discharge with

24-hr follow-up

(UA in boys < 1

year and girls <

2 years)

Figure 48-1. Pediatric fever diagnostic algorithm. CXR, chest x-ray; IM, intramuscu lar; LP, lumbar

pu ncture; SBI, serious bacterial infection; UA, urinalysis.

most commonly used decision-making tools for determining management of fever in well-appearing neonates and

infants (Table 48-1 ). Although all three have limitations,

they have attempted to create sensitive, specific screening

criteria to identify infants at low risk for SBI.

Lower risk stratification can be considered if the white

blood cell (WBC) count is between 5 and 15,000, band to

neutrophil ratio is <0.2, and urinalysis with <8 WBC per

high-power field. Clinical impression alone is not suffi ­

cient to forego lumbar puncture in this age group. The

decision to perform lumbar puncture depends on several

factors, including laboratory results, urinalysis, vaccination

status, and presence or absence of viral symptoms.

Well appearing children 3-36 months are at lower risk

for disseminated infections and can generally be managed

based on the nature of the infection, without an extensive

work-up for SBI. Fever in this age group is most commonly

caused by viral infections. The incidence of occult bacteremia

in well-appearing febrile children in this age group has

steadily decreased due to routine administration of both the

Hib and pneumococcal conjugate vaccine. Centers for

Disease Control and Prevention data now reflect that the current rate of occult bacteremia is < 1%. Furthermore, approximately 80% of pneumococcal bacteremia will resolves

spontaneously without intervention. Thus several acceptable

variations in management exist for this patient cohort.

The evaluation of well-appearing children age

3-36 months includes urinalysis and urine culture for girls

<2 years of age and boys < 1 year of age, particularly if they

are uncircumcised. A CXR may be performed if there are

signs of lower respiratory infection. If no source is

identified after this focused evaluation, reassurance and

CHAPTER 48

Table 48-1. Rochester, Philadel phia, and Boston criteria comparison.

 


heart rate, and location of the placenta.

MEDICAL DECISION MAKING

Delivery of a fetus is best done by obstetricians in a labor

and delivery unit. If time allows, the emergency physician

should attempt to transfer the patient to an appropriate

setting. In a hospital with no obstetric services, a precipitously delivering mother must be delivered by the emer ­

gency physician. If delivery is not imminent, the patient

may be transferred. If a patient needs to be transferred to

another hospital, she should be sent by an advanced life

support-equipped ambulance, as a patient in labor is c onsidered medically unstable (Figure 46-1).

Gravid fema le

with contractions

Prepare for

emergency del ivery

Partia lly di lated

and Obstetrician

in the hospital

.AFigure 46-1 . Emergency del ivery diagnostic algorithm.

CHAPTER 46

TREATMENT

If the decision is made to deliver the child in the ED, call

for obstetric and pediatric support if available. Large-bore

intravenous (IV) access should be obtained and fluids

started. Oxygen by nasal cannula is given to the mother,

especially if there are any signs of fetal distress. The infant

radiant warmer should be set up and in the room. Delivery

equipment should be set up including cord clamps,

scissors, suction, forceps, and neonatal resuscitation

equipment.

The mother is placed in the dorsal lithotomy position,

and the perineum is cleaned with povidone-iodine solution. Time permitting, the physician should be dressed in

gown, sterile gloves, hat, and mask. When the mother is

fully dilated, and the head is at + 3 station, the examiner

uses a towel and supports the perineum by gently putting

pressure on the fetal chin. The other hand is used to control the fetal occiput (Figure 46-2A). Slight pressure on the

occiput ensures a smooth delivery of the fetal head and

reduces tearing.

Once the fetal head is delivered, the physician should

suction the nose and mouth and check for a nuchal cord.

The mother should stop pushing at this point. If a nuchal

cord is present, it is pulled over the fetal head. If unable to

pull the cord over, it should be clamped in two places and

cut in the middle.

Next, the anterior shoulder is delivered by guiding the

head inferiorly with gentle traction. The posterior shoulder

is delivered next by traction upwards. This will also deliver

the rest of the infant (Figures 46-2B and 46-2C). If the

shoulders are not easily delivered, the physician should

consider shoulder dystocia as a complication. Once the

infant is delivered, the cord is clamped in 2 locations and

cut in the middle. The infant is wrapped, cleaned, and

taken to the infant warmer for evaluation.

Ideally, a second physician or experienced practitioner

can care for the newborn while the delivering physician

Figure 46-2. A. Del ivery of the head while putting pressure over the peri neum. B. Del ivering the anterior

shoulder. c. Del ivery of the posterior shoulder is performed with gentle upward traction, while su pporting the

head. Reprinted with permission from VanRooyen MJ, Scott JA. Chapter 1 05. Emergency Del ivery. In: Tintina IIi

JE, Stapczynski JS, Ma OJ, Cline OM, Cyd ulka RK, Meckler GO, eds. Tintinolli's Emergency Medicine: A

Comprehensive Study Guide. 7th ed. New York: McGraw-Hill, 201 1.

EMERGENCY DELIVERY

Table 46-1 . APGAR scoring.

Sign 0 Points

Activity Absent

Pulse Absent

Grimace No response

Appearance Blue-gray or pale

Respiration Absent

treats the mother. The newborn should be warmed, given

oxygen, and stimulated. The APGAR is performed at 1 and

5 minutes (Table 46- 1). Neonatal intubation should be

considered for poor tone, shallow respirations, and cyanosis. Once the infant is assessed, attention is directed back

to the mother, to deliver the placenta. The placenta should

deliver spontaneously, but it can be assisted with uterine

massage while pulling gently on the umbilical cord.

Pulling too forcefully can result in uterine inversion.

Complications of delivery include postpartum hemorrhage, shoulder dystocia, and breech presentations.

Although rare, these complications generally require the

assistance of an obstetrician.

Postpartum hemorrhage can occur immediately after

delivery or up to a few hours after delivery. The physician

should check for retained products, uterine atony, uterine

inversion, or vaginal lacerations that are contributing to the

blood loss. In the case of uterine atony, oxytocin can be given,

20 units in 1 L of Lactated Ringer's solution. Additionally,

misoprostol 1 mg can be given per rectum.

Shoulder dystocia is present when the fetus's anterior

shoulder becomes caught under the mother's pubic bone.

It is more common in diabetic mothers, obesity, and postmaturity of the fetus. The first clue to the physician that

shoulder dystocia is occurring is a retraction of the fetal

head toward the vagina immediately after it is delivered.

This is called the "turtle sign." In the event of a shoulder

dystocia, the mother's legs are flexed to a knee-chest position (McRobert maneuver). This rotates the pubic bone

over the anterior fetal shoulder. Second, an assistant provides firm suprapubic pressure to further disengage the

1 Point

Arms and legs flexed

<100 bpm

Grimace

Normal, except extremities

Slow, irregular

2 Point

Active movement

> 1 00 bpm

Sneeze, cough, pulls away

Normal over entire body

Good, crying

anterior shoulder. If this does not resolve the dystocia, an

episiotomy should be performed to enlarge the opening

and provide access to the posterior shoulder.

Breech presentations are ideally delivered by cesarean

section. Rapid bedside ultrasound can determine whether

the fetal head or another part is presenting. Breech presen ­

 


ous abortion. In the United States, about 2% of all pregnancies are ectopic pregnancies. Mortality in these women is due

to shock from intra-abdominal hemorrhage. In postmenopausal women with vaginal bleeding, 10% will be diagnosed

with cancer, the majority being endometrial cancer.

Ectopic pregnancy is one of the most important causes

of vaginal bleeding. Ectopic pregnancy occurs when a

1 81

• Ruptured ectopic pregnancy is a surgical emergency

requiring prompt intervention and gynecologic consultation.

• Patients with postmenopausal bleeding should be

referred to a gynecologist for endometrial biopsy to

exclude malignancy.

trophoblast implants at a site outside of the endometrium.

In most cases, the ectopic site is within the lateral two

thirds of the fallopian tube. Other sites include the medial

third of the fallopian tube, cornu (junction of the tube and

uterus), ovary, fimbria, cervix, and abdomen (Figure 43-1).

Risk factors for ectopic pregnancy include a history of salpingitis, use of an intrauterine device, a prior ectopic pregnancy, increased maternal age, use of fertility drugs, and

history of tubal ligation. Up to 42% of women with an

ectopic pregnancy have no risk factors.

CLINICAL PRESENTATION

..... History

A detailed history is essential. Determine the onset of bleeding, the date and duration of the last normal menstrual

period, the number of previous pregnancies, and the presence of any prior history of abnormal vaginal bleeding. Pain

may or may not be present. If pain is present, determine pain

characteristics such as location, quality, and duration.

Approximately 1 0% of patients with ectopic pregnancy will

present with bleeding only. Attempt to have the patient

quantify the amount of bleeding. Although variable, a

tampon or pad absorbs approximately 30 mL of blood. The

presence of clotted blood suggests brisk vaginal bleeding.

Inquire about previous gynecologic problems and

assess the risk factors for ectopic pregnancy.

CHAPTER 43

Tubal 95-96%

Interstitial and

£. Figure 43-1. Frequency of sites of ectopic pregnancy. Repri nted with permission from

Cunningham FG, Le�eno KJ, Bloom SL, Hauth JC, Rouse OJ, Spong CY. Chapter 1 o. Ectopic

Pr�g nancy. In: Cunnmgham FG, Leveno KJ, Bloom SL, Hauth JC, Rouse OJ, Spong cv, eds.

WJ/Iwms Obstetrics. 23rd ed. New York: McGraw-Hill, 201 0.

Symptoms of weakness, lightheadedness, shortness of

breath, or syncope suggest anemia from significant blood

loss. Determine the presence of other medical conditions

(eg, coagulopathies) or medications (eg, anticoagulants)

that may exacerbate vaginal bleeding.

� Physical Examination

Note the patient's blood pressure and pulse, specifically to

identify hypotension or a resting tachycardia. Look for

other signs of anemia such as general, mucosal, or nail bed

pallor. Before performing a pelvic examination, perform a

focused general examination, including the heart, lungs,

abdomen, and flank. Assess the abdomen for the presence

of tenderness, masses, guarding, and rebound. Peritoneal

signs may suggest infection or intraperitoneal blood.

For the pelvic examination, obtain the patient's consent

and ensure her privacy during the exam. Explain what you

are going to do. Ideally, both male and female examiners

should request that a chaperone be present. Perform the

exam with the patient in the lithotomy position. First, inspect

the external genitalia. Then, using a warmed, lubricated, and

appropriately sized vaginal speculum, determine the presence of blood, blood clots, tissue (products of conception), or

discharge in the vaginal vault. Visually inspect the cervix.

On bimanual examination, determine whether the cervical os is open or closed. An open os is present when the

tip of the examiner's index finger can easily pass through

the cervix. Women with a closed internal os should be

Table 43-1. Classification of spontaneous abortion.

Type Internal Cervical Os Products of Conception

Threatened Closed Not passed

Inevitable Open Not passed

Incomplete usually open Partially passed

Complete Closed Completely passed

considered to have a closed os, even if the external portion

of the os is open. The internal os and the presence of products of conception will allow classification of different

types of spontaneous abortions ( Table 43-1).

Next, estimate the size of the uterus (12 weeks at the

symphysis, 20 weeks at the umbilicus) by palpating the

uterine fundus on the abdomen with one hand and palpating the cervix with the index and middle fingers on the

other hand. Assess the cervix, uterus, and adnexa for tenderness or masses. Tenderness on pelvic examination is

present in more than 80% of patients with a ruptured

ectopic pregnancy.

DIAGNOSTIC STUDIES

� Laboratory

Urine pregnancy test is 99.4% sensitive for diagnosing

pregnancy at the time that a woman "misses" her period.

VAGI NAL BLEEDING

It detects the presence of the beta subunit of human

chorionic gonadotropin hormone ( �-hCG) produced by

the trophoblast in the patient's urine. A serum �-hCG

level is also obtained. In a normal pregnancy, �-hCG

levels double approximately every 2 days, peaking at

1 00,000 rniU/mL. Higher levels suggest trophoblastic

disease. An ectopic pregnancy can be present at any

�-hCG level; therefore, the initial �-hCG level cannot be

used to exclude ectopic pregnancy. Patients with repeat

�-hCG levels that decrease by >50% are at low risk for

ectopic pregnancy, whereas those with levels that do not

increase >66% are at high risk.

A serum hemoglobin is indicated in most patients with

vaginal bleeding, but especially those with a resting tachycardia, lightheadedness, or prolonged duration of bleeding

(2:3 weeks). Rh status should be obtained in pregnant

patients with vaginal bleeding.

� Imaging

In pregnant patients with vaginal bleeding, the presence of

an ectopic pregnancy must be excluded with a pelvic ultrasound performed by an emergency medicine physician or

radiology personnel. Ectopic pregnancy is excluded when

an intrauterine pregnancy (IUP) is visualized on pelvic

ultrasound. A heterotopic pregnancy (a simultaneous IUP

and an ectopic pregnancy), traditionally considered rare, is

more common in women receiving treatment for infertility. Patients with pelvic ultrasounds that demonstrate a

noncystic adnexal mass, moderate-large fluid in the culde-sac, an extrauterine gestational sac, or an empty uterus

(with �-hCG > 1,000 rniU/mL) should be considered high

risk for ectopic pregnancy. In 1 5-20% of patients, the initial pelvic ultrasound will be indeterminate (no evidence

of an IUP or an ectopic pregnancy). Of these indetermi ­

nate ultrasounds, 20% eventually will be diagnosed with

an ectopic pregnancy.

MEDICAL DECISION MAKING

In a patient with vaginal bleeding, the most essential information to determine is the hemodynamic status and a

urine pregnancy test. In the pregnant patient, the most

important role of the emergency department is to exclude

an ectopic pregnancy (Figure 43-2).

In patients with vaginal bleeding during the first

trimester of pregnancy, the diagnostic possibilities

include continuation of what will be a normal

pregnancy or an abnormal pregnancy ( ie, spontaneous

abortion; ectopic pregnancy; trophoblastic disease). In

nonpregnant patients, diagnostic possibilities include

dysfunctional uterine bleeding, uterine fibroids, malig ­

 


rostomy tubes. Patients with a solitary kidney, history of

renal transplant, or renal dysfunction should be discussed

with urology and admitted.

..... Discharge

Most patients with nephrolithiasis can be successfully

managed in the ED and safely discharged. They should

have adequate pain control and the ability to tolerate oral

NEPHROLITHIASIS

intake before discharge. Follow-up is recommended with

a primary care provider within 1 week for small ( <6 mm),

uncomplicated kidney stones in patients with a known

history of nephrolithiasis. Urology follow-up is recommended for patients with first time stones and large (>6

mrn) proximal stones, as these stones have a low likelihood ( < 1 Oo/o) of spontaneous passage. Patients should be

given prescriptions for opioid analgesics and a urine

strainer with instructions to strain all urine until stone

passage and to bring passed stones to their follow-up

appointment. Alpha blockers (tamulosin, terazosin, or

doxazosin) are prescribed for up to four weeks to relax

ureteral smooth muscles and increase the rate of stone

passage and decrease pain. Lastly, patients should be given

clear and specific discharge instructions to return to the

ED if they have fever, persistent vomiting, intractable pain,

or inability to urinate.

SUGGESTED READING

Manthey DE, Nicks BA. Urologic stone disease. I n: Tintinalli JE,

Stapczynsk.i JS, Ma OJ, Cline DM, Cydulka, RK, Meckler GD.

Tintinalli's Emergency Medicine: A Comprehensive Study

Guide. 7th ed. New York, NY: McGraw-Hill, 201 1 , 651-657.

Urinary Tract

Infections

Rebecca R. Roberts, MD

Key Points

• Differentiate a contami nated urinalysis from urinary

tract infection (UTI}. Obtain a catheterized urine

specimen when the diagnosis is in question.

• Send a urine culture only when appropriate

(pregnancy, recurrent UTI, pyeloneph ritis, urosepsis,

INTRODUCTION

A urinary tract infection (UTI) refers to an infection anywhere in the urinary system in the presence of bacteriuria

and symptoms. Cystitis is a lower tract infection of the

bladder. Pyelonephritis is an upper tract infection of the

kidney. An uncomplicated UTI occurs in patients without

comorbidities and with an anatomically and functionally

normal urinary tract. Complicated UTI occurs in patients

with a functional or anatomic abnormality of their urinary

tract or with the presence of serious comorbidities that

place the patient at risk for serious adverse outcomes.

These comorbidities include pregnancy, diabetes, immunocompromise, cancer, advanced age, and recent hospitalization or instrumentation. Anatomic factors that cause

obstruction of urine flow resulting in complicated UTI

include prostate enlargement, renal stones, obstructing

tumors, and ureteral reflux, compression, or stricture.

UTI is one of the most common bacterial infections.

In 2007, nearly 1 .7 million UTis were diagnosed in U.S.

emergency departments (EDs), and 12% required hospital admission. Neonates, girls, and young women are

at increased risk for infection. UTI is uncommon in

young men; however, men older than 55 years have an

increased risk due to incomplete bladder emptying from

prostatic hypertrophy. UTI is the leading cause of sepsis

immunosuppression, fever without a source, indwel ling

bladder catheter).

 


tis) or primary CNS lymphoma. Painless visual loss occurs

with CMV retinitis.

Gastrointestinal complaints. Difficulty swallowing

occurs with candidal esophagitis, and failure to improve

with fluconazole (Ditlucan) suggests CMV or herpes

esophagitis. Acute diarrhea may be caused by bacteria ( eg,

Salmonella), whereas chronic diarrhea may represent a

parasitic ( eg, Giardia, Cryptosporidium) or viral ( eg, CMV)

cause. Pancreatitis and kidney stones most often occur as a

result of antiretroviral therapy.

� Physical Examination

A comprehensive physical examination may not only help

provide a general picture of the overall health of the

patient, it can also help identify the source for any acute

presenting complaint. Some key systems to examine

include:

Vital signs. History of fever at home requires a workup, even if the patient is afebrile in the ED. Tachypnea and

hypoxia suggest PCP.

General appearance. Assess for respiratory distress.

Wasting, dehydration, and parietal hair loss are common in

patients with advanced AIDS.

Head and neck. Assess visual acuity and perform

funduscopic examination for possible CMV retinitis ("ketchup

and mayo" retinal findings). Perform oral examination for

Figure 37·1. Photograph showi ng patient with oral

ca ndid iasis.

candidiasis (thrush) and oral hairy leukoplakia (Figure 37-1).

Assess the neck for lymphadenopathy or meningismus.

Pulmonary. Auscultate for rales, rhonchi, or wheezes;

however, many patients with PCP will have normal breath

sounds.

Cardiovascular. Listen for new murmurs, suggesting

endocarditis, especially in the N drug user.

Gastrointestinal. Examine for evidence of peritonitis,

pancreatitis, or hepatobiliary disease, which may occur secondary to acute infection or antiretroviral medications.

Neurologic. Assess mental status and any focal deficits

(present in up to 60o/o of patients with toxoplasmosis,

though absent in many cases of cryptococcal meningitis).

Skin. Examine for Kaposi sarcoma, cellulitis, abscesses,

evidence of disseminated infection (endocarditis, fungal

disease, dMAC), or drug reactions.

DIAGNOSTI C STUDIES

� Laboratory

Complete Blood Count. Use the absolute lymphocyte

count as a correlation for the CD4 count. If the CD4 count

is unknown, an absolute lymphocyte count (ALC) can be

used to predict the CD4 count. The ALC is equal to the total

white blood cell count multiplied by the percentage of lymphocytes. An ALC of< 1 ,000/!!L predicts a CD4 count <200/

!!L. An ALC of >2,000/!!L predicts a CD4 count >200/!!L.

CHAPTER 37

Chemistry. Useful in patients with prolonged diarrhea,

dehydration, or wasting to assess glucose level, electrolytes,

and renal function. Can be helpful in patients presenting

with abdominal pain to check for lactic acidosis.

Liver profile, lipase, lactate dehydrogenase. In patients

with abdominal pain and j aundice. Lactate dehydrogenase

(LDH) is also useful in patients with s uspected PCP. Elevation

> 220 IU /L in patients with shortness of breath suggests PCP

(94% sensitive), and a normal LDH level suggests an alternative diagnosis.

Blood cultures. In patients with a fever without a

source and for suspected serious bacterial (including

mycobacterial), viral, or fungal infections.

Urine. Obtain a urinalysis and urine culture in all

febrile patients without a source. Many AIDS patients have

urinary tract infections without localizing symptoms. The

urinary histoplasma antigen can be useful in detecting disseminated histoplasmosis.

StooL Check for leukocytes, bacterial culture, ova, and

parasites (including microsporidia, Cryptosporidium, Isospora,

and Cyclospora) in patients with diarrhea or bloody stools.

Some causes of diarrhea may require biopsy for diagnosis.

Blood gas. An arterial blood gas should be performed

for patients with pulmonary complaints. Patients with

PCP and an elevated A-a gradient (>35 mmHg) or low

Pa02 ( <70 mmHg on room air) are candidates for adjunctive steroid therapy.

Viral load. Rarely used emergently to establish risk of

opportunistic infection.

.... Imaging

Chest x-ray. All HN-positive patients with pulmonary

symptoms or fever without a source. PCP classically shows

diffuse bilateral interstitial infiltrates, but findings vary

widely and can be normal (39%) or indistinguishable from

bacterial pneumonia (Figure 37-2).

Head computed tomography ( CT) scan with contrast.

All patients with neurologic symptoms (Figure 37-3).

Brain magnetic resonance imaging (MRI) with contrast. Consider for patients with focal neurologic findings

but minimal or only subtle changes on head CT. Some

lesions of progressive multifocal leukoencephalopathy

(PML) or toxoplasmosis are seen only on MRI.

Abdominal CT scan and ultrasound. Immuno suppression masks normal inflammatory responses to serious

intra-abdominal pathology such as appendicitis and biliary

disease. Maintain a low threshold for imaging patients with

abdominal pain.

 


elevated protein

Tuberculous or fungal

meningitis

Figure 35-1. Meningitis diag nostic algorithm. AMS, altered mental status; CSF, cerebrospinal flu id; IV,

intravenous, LP, lumbar puncture.

general guidelines may be helpful to broadly characterize

CSF findings in many cases, several studies have demon ­

strated that no single laboratory finding can accurately

categorize the cause of CSF pleocytosis in all patients

(Figure 35-1).

CSF studies for patients with encephalitis will lead to

similarly abnormal results, with increased numbers of white

blood cells in the CSF, generally with a lymphocytic predominance. Results may also reveal increased numbers of red blood

cells in the CSF owing to neuronal cell death leading to edema,

hemorrhage, and necrosis when encephalitis is present.

TREATMENT

For patients with suspected bacterial meningitis, empiric IV

antibiotic therapy and admission to the hospital is recommended (Table 35-2). Recommendations for pediatric

patients are based on patient age. For neonates less than

1 month, empiric IV therapy includes ampicillin and cefotaxirne (alternative is ampicillin and gentamicin). Children

1 to 3 months should be given ampicillin and cefotaxirne,

Table 35-2. Recommended empiric therapy for

adu lts with suspected bacterial meningitis.'''

Patient Age IV Empiric Therapy*

Adults <SO years Ceftriaxone or cefotaxime and vancomycin

Adults 2:50 years Ceftriaxone or cefotaxime and vancomycin

and ampicillin

Readers should consult local infectious disease special ists for

recommended empiric antibiotic therapy in your local region.

''Remember to add acyclovir in cases of possible HSV encephal itis.

CHAPTER 35

and for those older than 3 months, empiric therapy includes

ampicillin or ceftriaxone, and vancomycin. Patients with

severe disease may require intensive care unit level care

depending on the clinical circumstances.

The role of adjunctive dexamethasone for patients with

bacterial meningitis remains somewhat uncertain, as

recent work has questioned the value of this treatment that

had previously been strongly recommended to reduce

mortality and poor neurologic outcomes. For patients in

high-income countries, there may be benefit to treatment

with IV dexamethasone that is initiated before or at the

same time as antibiotic treatment.

In patients with suspected bacterial meningitis who

need a CT scan of the brain before LP, blood cultures

should be drawn and empiric antimicrobial therapy administered before CT to avoid additional delays to beginning

treatment.

The treatment for most cases of encephalitis is supportive care. HSV encephalitis is the only cause of this disease

with a specific treatment: N acyclovir.

DISPOSITION

.... Admission

Patients who are diagnosed with bacterial meningitis or

viral encephalitis should be admitted to the hospital for

monitoring, N antimicrobial agents, and other adjunctive

therapies. There may be clinical ambiguity regarding disposition for patients who are clinically well appearing but have

mildly elevated white blood cell levels in the CSF suggestive

of aseptic meningitis. One option for such patients may

include hospital admission for observation with or without

empiric antibiotic therapy, pending CSF culture results.

..... Discharge

In some circumstances, patients with suspected viral meningitis may be appropriate for outpatient management

with close follow-up and strict return precautions. When

considering discharge home for outpatient management of

presumed viral meningitis, it is important to assess the

patient's support system, reliability, availability of close

follow-up, and mechanisms for contacting the patient if

CSF culture results are unexpectedly positive.

SUGGESTED READING

Fitch MT, Abrahamian FM, Moran GJ, Talan DA. Emergency

department management of meningitis and encephalitis.

Infect Dis Clin North Am. 2008;22:33-52, v-vi.

Fitch MT, van de Beek D. Emergency diagnosis and treatment of

adult meningitis. Lancet Infect Dis. 2007;7:19 1-200.

Loring KE, Tintinalli JE. Central nervous system and spinal

infections.

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